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Found 11 of ki for drug = Hyserpin
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory constant for cytochrome P450 2D6More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  4.60nMAssay Description:Apparent inhibitory constant (Ki) for Bufuralol 1'-hydroxylation by human liver microsomesMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of partially purified cytochrome P450 2D6 1'-hydroxybufuralol formationMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  13nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  14nMAssay Description:Inhibition of 1'-hydroxybufuralol formation by human liver microsomesMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030612((7aR,8S,11aS,12aS)-8-Methyl-5,6,7a,8,11a,12,12a,13...)
Affinity DataKi:  289nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed