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Found 746 with Last Name = 'ahmad' and Initial = 'm'
TargetGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50356009(CHEMBL1911368)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of GFAT in presence of glutamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50356009(CHEMBL1911368)
Affinity DataKi:  300nMAssay Description:Noncompetitive inhibition of GFAT in presence of fructose-6-phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611067(CHEMBL5277168)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611073(CHEMBL5276070)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611232(CHEMBL5283867)
Affinity DataIC50:  2nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate incubated for 30 secs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611064(CHEMBL316846)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611065(CHEMBL5267453)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611066(CHEMBL5279940)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611074(CHEMBL5278033)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611068(CHEMBL5280463)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611069(CHEMBL5265839)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611070(CHEMBL5289245)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611071(CHEMBL5269974)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611072(CHEMBL5290253)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Government College University

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341785((1R,2R)-2-(3'-fluoro-4'-(3-phenylureido)biphenylca...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656485((2R,3S,4S,5R)-4-[[3-[2-(difluoromethoxy)-3,4-diflu...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656561(US11919887, Compound 116 | US11919887, Compound 93...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656516(US11919887, Compound 44 | rel-(2R,3S,4S,5R)-4-[[3-...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656521(US11919887, Compound 52 | rel-(2R,3S,4S,5R)-N-(3-c...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656491(US11919887, Compound 17 | US11919887, Compound 53 ...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656524((2R,3S,4S,5R)-4-[[3-(2-ethoxy-3,4-difluoro-phenyl)...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656493((2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656557(US11919887, Compound 89 | rel-(2S,3R,4R,5S)-4-[[3-...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656561(US11919887, Compound 116 | US11919887, Compound 93...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656562(US11919887, Compound 94)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656477(US11919887, Compound 3b | rel-(2S,3R,4R,5S)-4-[[3-...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656481((2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656483((2R,3S,4S,5R)-4-[[3-(2-ethoxy-3,4-difluoro-phenyl)...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656485((2R,3S,4S,5R)-4-[[3-[2-(difluoromethoxy)-3,4-diflu...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656489(US11919887, Compound 15 | rel-(2S,3R,4R,5S)-N-(3-)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656491(US11919887, Compound 17 | US11919887, Compound 53 ...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656492((2R,3S,4S,5R)-4-[[3-[2-(difluoromethoxy)-3,4-diflu...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656493((2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656499(US11919887, Compound 25 | rel-(2R,3S,4S,5R)-4-[[3-...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656481((2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
VERTEX PHARMACEUTICALS INCORPORATED

US Patent
LigandPNGBDBM656506(US11919887, Compound 32 | rel-(2R,3S,4S,5R)-N-(3-c...)
Affinity DataIC50: <10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341766(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM69641(1,3-Diphenyl-1H-pyrazole-4-carbaldehyde | 1,3-diph...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate incubated for 30 secs by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611226(CHEMBL5278905)
Affinity DataIC50:  17nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate incubated for 30 secs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Equus caballus (Horse))
Government College Women University

Curated by ChEMBL
LigandPNGBDBM50004244(CHEMBL3237461)
Affinity DataIC50:  17nMAssay Description:Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611228(CHEMBL5275104)
Affinity DataIC50:  17nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate incubated for 30 secs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611227(CHEMBL5288954)
Affinity DataIC50:  17nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate incubated for 30 secs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Government College University

Curated by ChEMBL
LigandPNGBDBM39862(Deprenyl | METHYL-(1-METHYL-2-PHENYL-ETHYL)-PROP-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MAO-B in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Government College Women University

Curated by ChEMBL
LigandPNGBDBM50004238(CHEMBL3237453)
Affinity DataIC50:  26nMAssay Description:Inhibition of BuChE in equine serum using butyrylthiocholine chloride as substrate preincubated with enzyme for 10 mins prior to substrate challenge ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341768(4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carbony...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341778(4-(4-{5-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50341760(2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Aci...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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