Affinity DataKi: 8.25E+4nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes assessed as inhibition constant by Kitz-Wilson plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.25E+4nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes assessed as inhibition constant by Kitz-Wilson plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.30E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Concentration required for inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair