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Found 3 of Enz. Inhib. data with enzyme = 'Cytochrome P450 2D6' and Substrate = 'BDBM21362'
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9169224, 150 | US9688664, Comparator Compound)
Affinity DataIC50:  3.20E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  2.40E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataIC50:  1.96E+5nMpH: 7.4 T: 2°CAssay Description:The effect of compound on cytochrome P450 (CYP) enzyme catalytic activity was determined in human liver microsomes, using a cocktail of probe substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed