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Found 45 of Enz. Inhib. data with enzyme = 'Interstitial collagenase' and Substrate = 'to-be-curated'
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataIC50:  120nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM651530(Preparation of 1-(prop-2-ynyl)-N-(tetrahydro-2H-py...)
Affinity DataIC50:  860nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413568((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(4-fluorobenzoyl...)
Affinity DataIC50: <1.00E+3nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413584((2S,4R)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydro...)
Affinity DataIC50: <1.00E+3nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM50453825(CHEMBL4215407 | US10556883, Compound 19a)
Affinity DataIC50:  4.46E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50:  4.63E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413585((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl)amino...)
Affinity DataIC50:  6.10E+3nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM430278(US10556883, Compound 28b)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM50453844(CHEMBL4206013 | US10556883, Compound 22)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM430277(US10556883, Compound 26f)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM430271(US10556883, Compound 10)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM430272(US10556883, Compound 11)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50: >1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM379697(US9926281, Compound 255)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM379565(US9926281, Compound 55)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM379558(US9926281, Compound 40)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM379557(US9926281, Compound 36)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM379553(US9926281, Compound 27)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400682(US10000476, Compound I-41)
Affinity DataIC50:  9.30E+4nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400727(US10000476, Compound I-86)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400699(US10000476, Compound I-58 | US10000476, Compound I...)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400703(US10000476, Compound I-62)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400681(US10000476, Compound I-40)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400668(US10000476, Compound I-27)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400651(US10000476, Compound I-10 | US10000476, Compound I...)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400231(US10000476, Compound I-1 | US10000476, Compound I-...)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM400650(US10000476, Compound I-9)
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413590((2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-meth...)
Affinity DataIC50: >2.00E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  3.65E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413571((2S)-1-butanoyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluorob...)
Affinity DataIC50:  4.73E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413569((2S)-1-acetyl-N-[(1S)-1-[[(1S)-3-[(3,5-difluoroben...)
Affinity DataIC50:  4.94E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413582((2S)-1-[(2S)-2-[[(2S)-2-[butanoyl(methyl)amino]-3-...)
Affinity DataIC50:  6.07E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413577((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  6.61E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413572((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  6.68E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413570((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  6.82E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413579((2 S)-1-[(2S)-2-[acetyl(methyl)amino]-3-phenyl-pro...)
Affinity DataIC50:  9.13E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM651533(1,5-Click Carboranyl MMP-18 HCl Salt | US20240050...)
Affinity DataIC50: >1.00E+7nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM651531(1,4-Click Carboranyl MMP-18 HCl Salt | US20240050...)
Affinity DataIC50: >1.00E+7nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413583((2S)—N-[(1S)-1-[[(1S)-3-benzamido-1-(hydroxyc...)
Affinity DataIC50:  1.08E+7nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413576((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  1.14E+7nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413580((2 S)-1-[(2S)-2-[acetyl(methyl)amino]propanoyl]-N-...)
Affinity DataIC50:  1.49E+7nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413574((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  2.47E+7nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413573((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50:  2.56E+7nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Loyola University of Chicago

US Patent
LigandPNGBDBM413581((2S)-1-[3-[acetyl(methyl)amino]propanoyl]-N-[(1S)-...)
Affinity DataIC50:  2.00E+8nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent