Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 50010036
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090249(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  6nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50077058(3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfon...)
Affinity DataKi:  26nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090244(3,3-Dimethyl-6-[3-oxo-3-(4-pyridin-4-ylmethyl-pipe...)
Affinity DataKi:  27nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090250(3-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090247(6-[3-(4-Acetyl-piperazin-1-yl)-3-oxo-propyl]-3,3-d...)
Affinity DataKi:  34nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090243(6-(2-Hydroxy-ethyl)-3,3-dimethyl-1,2,3,4-tetrahydr...)
Affinity DataKi:  39nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090246(3,3-Dimethyl-6-(2-ureido-ethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  47nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090238(3,3-Dimethyl-6-{3-[4-(2-morpholin-4-yl-2-oxo-ethyl...)
Affinity DataKi:  57nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090245(6-Hydroxymethyl-3,3-dimethyl-1,2,3,4-tetrahydro-qu...)
Affinity DataKi:  64nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090248(CHEMBL43397 | Methyl-carbamic acid 8-{(S)-1-benzot...)
Affinity DataKi:  77nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090241(3-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  82nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090242(4-(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro...)
Affinity DataKi:  94nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090253(6-(3-Hydroxy-propyl)-3,3-dimethyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  119nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090251(6-(2-Methoxy-ethoxymethoxymethyl)-3,3-dimethyl-1,2...)
Affinity DataKi:  125nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090240(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-et...)
Affinity DataKi:  359nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090239((8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-e...)
Affinity DataKi:  500nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090252(8-{(S)-1-Benzothiazol-2-ylmethyl-2-[4-(2-fluoro-et...)
Affinity DataKi:  723nMAssay Description:Evaluated for the binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090238(3,3-Dimethyl-6-{3-[4-(2-morpholin-4-yl-2-oxo-ethyl...)
Affinity DataKi:  1.22E+4nMAssay Description:Inhibitory activity against Serine protease chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090238(3,3-Dimethyl-6-{3-[4-(2-morpholin-4-yl-2-oxo-ethyl...)
Affinity DataKi:  1.53E+5nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50090238(3,3-Dimethyl-6-{3-[4-(2-morpholin-4-yl-2-oxo-ethyl...)
Affinity DataKi:  2.12E+5nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed