Compile Data Set for Download or QSAR
maximum 50k data
Found 21 Enz. Inhib. hit(s) with all data for entry = 50017022
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50:  50nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176486((5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H...)
Affinity DataIC50:  130nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176480((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]th...)
Affinity DataIC50:  140nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176488(((R)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50:  170nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176479((5-bromo-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  190nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176476((5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  320nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176483((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50:  750nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176489((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]fu...)
Affinity DataIC50:  1.49E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176481((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176485(((S)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50:  2.85E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176482((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]fur...)
Affinity DataIC50:  4.46E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176487(((S)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50:  5.36E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176490((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]fur...)
Affinity DataIC50:  1.63E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176477((5,8-dichloro-1-methyl-3,4-dihydro-1H-benzo[4,5]th...)
Affinity DataIC50:  1.76E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176474((5,8-dichloro-1-methyl-3,4-dihydro-1H-benzo[4,5]fu...)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176484((1-propyl-3,4-dihydro-1H-benzo[4,5]furo[2,3-c]pyra...)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176478((6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4...)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176491((1-propyl-3,4-dihydro-1H-benzo[4,5]thieno[2,3-c]py...)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50: >7.50E+4nMAssay Description:Inhibition of HCV NS3 helicaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataEC50:  3.20E+3nMAssay Description:Reduction of viral RNA and protein in Huh7 cells containing HCV sub-genomic repliconMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed