Compile Data Set for Download or QSAR
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Found 12 Enz. Inhib. hit(s) with all data for entry = 10637
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556275(US11345701, Compound 2-1)
Affinity DataIC50:  14.5nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556273(US11345701, Compound 1-1)
Affinity DataIC50:  16.6nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(4-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  17.8nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50514402(CHEMBL4535757 | US11345701, Compound Amg-510)
Affinity DataIC50:  24.5nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556277(US11345701, Compound 3-1)
Affinity DataIC50:  25.4nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556274(4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-7-(2-ami...)
Affinity DataIC50:  30.7nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556282(US11345701, Compound 7-1)
Affinity DataIC50:  36.7nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556278(US11345701, Compound 4-1)
Affinity DataIC50:  40.9nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(4-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  48.8nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556272(4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-7-(3-ami...)
Affinity DataIC50:  70.1nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556274(4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-7-(2-ami...)
Affinity DataIC50:  681nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM556279(4-((3S,5R)-4-acryloyl-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  774nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent