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Target
Carbonic anhydrase 5B, mitochondrial
Ligand
BDBM50449818
Substrate
n/a
Meas. Tech.
ChEMBL_1816903 (CHEMBL4316477)
Kd
67±n/a nM
Citation
 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5B, mitochondrial
Synonyms:
Carbonic anhydrase VB (CA VB) | CA-VB | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase 5B (CA VB) | Carbonate dehydratase VB | Carbonic anhydrase 5B, mitochondrial | CAH5B_HUMAN | CA5B | Carbonic anhydrase V | Carbonic Anhydrase VB
Type:
Enzyme
Mol. Mass.:
36440.83
Organism:
Human
Description:
Human (cloned) isozyme
Residue:
317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
  
Inhibitor
Name:
BDBM50449818
Synonyms:
CHEMBL4165896
Type:
Small organic molecule
Emp. Form.:
C12H14Cl2N2O5S
Mol. Mass.:
369.23
SMILES:
COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O
Structure:
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